Standard medical education teaches interventions that work — but often treats markers instead of mechanisms. These pieces explore the gap between what we prescribe and what the evidence actually supports.
What boards teach
Migraine is a neurovascular disorder treated by blocking CGRP or constricting cranial vessels with triptans — both reduce attack frequency and abort pain.
What evidence says
CGRP and pain are downstream signals of a neuronal energy deficit. Blocking them silences the alarm without addressing the ATP shortfall driving cortical spreading depression.